• Yvan Vandenplas, Elisabeth De Greef, I Xinias, O Vrani, A Mavroudi, M Hammoud, F Al Refai, M C Khalife, A Sayad, P Noun, A Farah, G Makhoul, R Orel, M Sokhn, A L'Homme, M P Mohring, B Abou Merhi, J Boulos,... more H El Masri, C Halut, and Allar Study Group. less
• UZ Brussel, Department of Pediatrics, Vrije Universiteit Brussel, Brussels, Belgium. Electronic address: yvan.vandenplas@uzbrussel.be.
• Nutrition. 2016 Feb 1; 32 (2): 206-12.

ObjectivesCow's milk allergy (CMA) is treated in formula-fed infants with an extensive protein hydrolysate. This study aimed to evaluate the nutritional safety of a non-thickened and thickened extensively casein hydrolyzed protein formula (NT- and T-eCHF) in infants with CMA.MethodsInfants younger than 6 mo old with a positive cow milk challenge test, positive IgE, or skin prick test for cow milk were selected. Weight and length were followed during the 6 mo intervention with the NT-eCHF and T-eCHF.ResultsA challenge was performed in 50/71 infants with suspected CMA and was positive in 34/50. All children with confirmed CMA tolerated the eCHF. The T-eCHF leads to a significant improvement of the stool consistency in the whole population and in the subpopulation of infants with proven CMA. Height and weight evolution was satisfactory throughout the 6 mo study.ConclusionsThe eCHF fulfills the criteria of a hypoallergenic formula and the NT- and T-eCHF reduced CMA symptoms. Growth was within normal range.Copyright © 2016 Elsevier Inc. All rights reserved.

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