• Am. J. Respir. Crit. Care Med. · May 2011

    Multicenter Study Clinical Trial

    Serum PARC/CCL-18 concentrations and health outcomes in chronic obstructive pulmonary disease.

    • Don D Sin, Bruce E Miller, Annelyse Duvoix, S F Paul Man, Xuekui Zhang, Edwin K Silverman, John E Connett, Nicholas A Anthonisen, Robert A Wise, Donald Tashkin, Bartolome R Celli, Lisa D Edwards, Nicholas Locantore, William Macnee, Ruth Tal-Singer, David A Lomas, and ECLIPSE Investigators.
    • UBC James Hogg Research Centre, St. Paul's Hospital, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6 Canada. don.sin@hli.ubc.ca
    • Am. J. Respir. Crit. Care Med. 2011 May 1; 183 (9): 1187-92.

    RationaleThere are no accepted blood-based biomarkers in chronic obstructive pulmonary disease (COPD). Pulmonary and activation-regulated chemokine (PARC/CCL-18) is a lung-predominant inflammatory protein that is found in serum.ObjectivesTo determine whether PARC/CCL-18 levels are elevated and modifiable in COPD and to determine their relationship to clinical end points of hospitalization and mortality.MethodsPARC/CCL-18 was measured in serum samples from individuals who participated in the ECLIPSE (Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints) and LHS (Lung Health Study) studies and a prednisolone intervention study.Measurements And Main ResultsSerum PARC/CCL-18 levels were higher in subjects with COPD than in smokers or lifetime nonsmokers without COPD (105 vs. 81 vs. 80 ng/ml, respectively; P < 0.0001). Elevated PARC/CCL-18 levels were associated with increased risk of cardiovascular hospitalization or mortality in the LHS cohort and with total mortality in the ECLIPSE cohort.ConclusionsSerum PARC/CCL-18 levels are elevated in COPD and track clinical outcomes. PARC/CCL-18, a lung-predominant chemokine, could be a useful blood biomarker in COPD.

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