• Sumii Yamamoto, Hiroshi Yamaguchi, Misa Sakaguchi, Soichiro Yamashita, and Tsuyoshi Satsumae.
• Department of Anesthesia and Critical Care Medicine, Iwaki Kyoritsu General Hospital, Uchigo, Iwaki, Fukushima, Japan.
• J Clin Anesth. 2003 Nov 1; 15 (7): 525-9.

Study ObjectiveTo demonstrate the effect of preoperative and intraoperative, small-dose intravenous (IV) droperidol on postoperative pain relief in orthopedic patients given general anesthesia with morphine.DesignRandomized, double-blind, prospective study.SettingUniversity-affiliated hospital.Patients84 ASA physical status I and II patients undergoing shoulder rotator-cuff repair with general anesthesia.InterventionsPatients were randomly assigned to one of three groups: Group P (n = 27) wee given droperidol 10 microg/kg IV before skin incision; Group A (n = 30) received droperidol 10 microg/kg IV after skin incision; and Group C (n = 27) served as controls. General anesthesia consisted of sevoflurane and nitrous oxide in oxygen and IV morphine 0.2 mg/kg, which was given before skin incision.MeasurementsThe degree of postoperative pain as assessed by postoperative pain scores and the number of supplemental analgesics given, and the frequency of postoperative nausea and vomiting, nightmares, and respiratory depression were compared among the three groups. A p-value < 0.05 was considered statistically significant.Main ResultsThe postoperative pain score distribution was significantly greater in smaller values in Groups P and A than in Group C (p < 0.01). The number of supplemental analgesics given in the first 18 hours postoperatively was significantly smaller in Group P than in Groups A or C (p < 0.05).ConclusionsPreoperative IV droperidol resulted in improved postoperative pain relief inpatients undergoing shoulder rotator cuff surgery with general anesthesia using IV morphine.

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