• Stavros M Stivaros, Mark R Radon, Reneta Mileva, Daniel J A Connolly, Patricia E Cowell, Nigel Hoggard, Neville B Wright, Vivian Tang, Ann Gledson, Ruth Batty, John A Keane, and Paul D Griffiths.
• Academic Unit of Paediatric Radiology, Royal Manchester Children's Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK. Stavros.Stivaros@manchester.ac.uk.
• Pediatr Radiol. 2016 Jan 1; 46 (1): 73-81.

BackgroundBirth-related acute profound hypoxic-ischaemic brain injury has specific patterns of damage including the paracentral lobules.ObjectiveTo test the hypothesis that there is anatomically coherent regional volume loss of the corpus callosum as a result of this hemispheric abnormality.Materials And MethodsStudy subjects included 13 children with proven acute profound hypoxic-ischaemic brain injury and 13 children with developmental delay but no brain abnormalities. A computerised system divided the corpus callosum into 100 segments, measuring each width. Principal component analysis grouped the widths into contiguous anatomical regions. We conducted analysis of variance of corpus callosum widths as well as support vector machine stratification into patient groups.ResultsThere was statistically significant narrowing of the mid-posterior body and genu of the corpus callosum in children with hypoxic-ischaemic brain injury. Support vector machine analysis yielded over 95% accuracy in patient group stratification using the corpus callosum centile widths.ConclusionFocal volume loss is seen in the corpus callosum of children with hypoxic-ischaemic brain injury secondary to loss of commissural fibres arising in the paracentral lobules. Support vector machine stratification into the hypoxic-ischaemic brain injury group or the control group on the basis of corpus callosum width is highly accurate and points towards rapid clinical translation of this technique as a potential biomarker of hypoxic-ischaemic brain injury.

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