• J Perinatol · Feb 2010

    Case Reports

    Case of chest-wall rigidity in a preterm infant caused by prenatal fentanyl administration.

    • S Eventov-Friedman, I Rozin, and E S Shinwell.
    • Department of Neonatology, Kaplan Medical Center, Rehovot, Israel.
    • J Perinatol. 2010 Feb 1;30(2):149-50.

    AbstractThe inability to appropriately ventilate neonates shortly after their birth could be related in rare cases to chest-wall rigidity caused by the placental transfer of fentanyl. Although this adverse effect is recognized when fentanyl is administered to neonates after their birth, the prenatal phenomenon is less known. Treatment with either naloxone or muscle relaxants reverses the fentanyl effect and may prevent unnecessary excessive ventilatory settings.

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