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Surg. Oncol. Clin. N. Am. · Jan 2009
ReviewThyroid cancer genetics: multiple endocrine neoplasia type 2, non-medullary familial thyroid cancer, and familial syndromes associated with thyroid cancer.
- Melanie L Richards.
- Department of Surgery, Mayo Clinic, Rochester, MN 55905, USA. richards.melanie@mayo.edu
- Surg. Oncol. Clin. N. Am. 2009 Jan 1;18(1):39-52, viii.
AbstractFamilial thyroid cancer accounts for 25% of medullary thyroid cancer (MTC) and 5% of non-medullary thyroid cancer. All patients who have familial MTC have one of three variants of multiple endocrine neoplasia type 2 that are defined by specific mutations in the rearranged during transfection (RET) proto-oncogene. Patients who have familial nonmedullary familial thyroid cancer most likely have a mutation that is autosomal dominant with reduced penetrance. Thyroid cancer also is associated with a number of familial syndromes. This article focuses on the genetics and management of familial thyroid cancers and the syndromes associated with thyroid cancer.
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