• Brain research bulletin · Jan 2015

    Review

    Molecular pathways of mitochondrial dysfunctions: possible cause of cell death in anesthesia-induced developmental neurotoxicity.

    • Li Li, Qiong Yu, and Weimin Liang.
    • Department of Anesthesiology, Huashan Hospital, Fudan University, Shanghai 200040, People's Republic of China. Electronic address: mazuilili@126.com.
    • Brain Res. Bull. 2015 Jan 1;110:14-9.

    AbstractThe effect of anesthesia on the developing brain has attracted more attention and arguments. This review summarizes various studies on developmental neurotoxicity induced by anesthesia, particularly focuses on the function of the mitochondrial dysfunction. Experimental results present evidence that general anesthesia can cause mitochondrial dysfunction via complex pathways, including oxidative stress, electron transport chain dysfunction, mitochondrial dynamics, calcium homeostasis, and mitochondrion-dependent apoptotic pathway. Hence, the molecular processes of mitochondrial dysfunction should be understood to develop novel therapeutic strategies that can prevent anesthesia-induced neurotoxicity and provide neuroprotection against developmental central nervous system.Copyright © 2014. Published by Elsevier Inc.

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