• Xiao-dong Wang, Xi-min Huo, Mei-xian Xu, Wen-jin Geng, Yan-mei Guo, Li-jing Cao, Hui Sun, Xiao-na Shi, Jun-E Li, Hai-yan Shi, Pan Li, and Lei Kang.
• Department of Critical Care Medicine, Hebei Provincial Children's Hospital, Shijiazhuang 050031, Hebei, China.
• Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2013 Apr 1;25(4):207-10.

ObjectiveTo investigate the value of timing of antibiotics in pediatric septic shock.MethodsEighty children with septic shock treated with bundle treatment in Department of Critical Care Medicine were retrospectively analyzed. Eighty children with septic shock were divided into observation group (n=40, anti-infection therapy within 1 hour after admission) and control group (n=40, anti-infection therapy 1-6 hours after admission). The contents of lactate, C-reaction protein (CRP) and procalcitonin (PCT) were compared between two groups at admission and 24 hours and 72 hours after admission.ResultsLactate in the observation group was significantly lower than that of the control group within the first 24 hours after admission (8.65 ± 2.84 mmol/L vs. 11.75 ± 3.20 mmol/L, P<0.01). CRP in the observation group was significantly lower than that of the control group 24 hours and 72 hours after admission (66.25 ± 8.55 mg/L vs. 91.77 ± 7.71 mg/L, 22.03 ± 7.46 mg/L vs. 50.11 ± 7.30 mg/L, both P<0.01). PCT in the observation group was significantly lower than that of the control group 72 hours after admission (0.67 ± 0.31 μg/L vs. 1.16 ± 0.25 μg/L, P<0.01). Time for shock recovery in the observation group was significantly shorter than that of the control group (6.80 ± 3.70 hours vs. 12.80 ± 3.63 hours, P<0.05), but no statistical difference in mortality rate between groups was found [5% (2/40) vs. 10% (4/40), P>0.05].ConclusionWith the early empirical anti-infection treatment in pediatric septic shocked patients, time for recovery from shock can be shortened and successful rate of resuscitation can be improved.

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