• Ann Pharmacother · Jun 2002

    Review Meta Analysis

    Fomepizole as an antidote for ethylene glycol poisoning.

    • Marisa Battistella.
    • University Health Network - Pharmacy Department ENG 260, 200 Elizabeth St., Toronto, Ontario M5G 2C4, Canada. marisa.battistella@uhn.on.ca
    • Ann Pharmacother. 2002 Jun 1;36(6):1085-9.

    ObjectiveTo assess the use of fomepizole in the treatment of ethylene glycol poisoning in the absence of hemodialysis.Data SourcesA MEDLINE search (1966-May 2001) of English-language literature pertaining to the use of fomepizole in ethylene glycol poisoning was performed. Key search terms included fomepizole, ethylene glycol poisoning, and hemodialysis. References cited in those articles were also evaluated.Data SynthesisResults from a number of case reports and a prospective trial suggest that fomepizole is a safe and effective antidote in the treatment of ethylene glycol poisoning.ConclusionsCase reports and 1 prospective trial have shown that, in the absence of both renal dysfunction and significant metabolic acidosis, the use of fomepizole should obviate the need for hemodialysis. However, the decision to add hemodialysis in the treatment of ethylene glycol poisoning based on plasma ethylene glycol concentrations is still debatable. A randomized, controlled trial is needed to determine the exact criteria for adding hemodialysis.

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