• Andrew L Wentland, Oliver Wieben, Dhanansayan Shanmuganayagam, Christian G Krueger, Jennifer J Meudt, Daniel Consigny, Leonardo Rivera, Patrick E McBride, Jess D Reed, and Thomas M Grist.
• Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA; Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
• J Magn Reson Imaging. 2015 May 1;41(5):1475-85.

PurposeTo assess measurements of pulse wave velocity (PWV) and wall shear stress (WSS) in a swine model of atherosclerosis.Materials And MethodsNine familial hypercholesterolemic (FH) swine with angioplasty balloon catheter-induced atherosclerotic lesions to the abdominal aorta (injured group) and 10 uninjured FH swine were evaluated with a 4D phase contrast (PC) magnetic resonance imaging (MRI) acquisition, as well as with radial and Cartesian 2D PC acquisitions, on a 3T MR scanner. PWV values were computed from the 2D and 4D PC techniques, compared between the injured and uninjured swine, and validated against reference standard pressure probe-based PWV measurements. WSS values were also computed from the 4D PC MRI technique and compared between injured and uninjured groups.ResultsPWV values were significantly greater in the injured than in the uninjured groups with the 4D PC MRI technique (P = 0.03) and pressure probes (P = 0.02). No significant differences were found in PWV between groups using the 2D PC techniques (P = 0.75-0.83). No significant differences were found for WSS values between the injured and uninjured groups.ConclusionThe 4D PC MRI technique provides a promising means of evaluating PWV and WSS in a swine model of atherosclerosis, providing a potential platform for developing the technique for the early detection of atherosclerosis.© 2014 Wiley Periodicals, Inc.

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