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Sarcoidosis Vasc Dif · Oct 2012
Case ReportsChest wall shrapnel-induced beryllium-sensitization and associated pulmonary disease.
- E Fireman, A Bar Shai, Y Lerman, M Topilsky, P D Blanc, L Maier, L Li, S Chandra, J M Abraham, I Fomin, G Aviram, and J L Abraham.
- Institute of Pulmonary and Allergic Diseases, National Service for Interstitial Lung Diseases, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. fireman@tasmc.health.gov.il
- Sarcoidosis Vasc Dif. 2012 Oct 1;29(2):147-50.
AbstractChronic beryllium disease (CBD) is an exposure-related granulomatous disease mimicking sarcoidosis. Beryllium exposure-associated disease occurs mainly via inhalation, but skin may also be a source of sensitization. A 65-year-old male with a history of war-related shrapnel wounds was initially diagnosed with pulmonary sarcoidosis. Twenty years later, the possibility of a metal-related etiology for the lung disease was raised. A beryllium lymphocyte proliferation test, elemental analysis of removed shrapnel, and genetic studies were consistent with a diagnosis of CBD. This case demonstrates that retained beryllium-containing foreign bodies can be linked to a pathophysiologic response in the lung consistent with CBD.
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