• J. Toxicol. Clin. Toxicol. · Jan 2003

    Case Reports

    Irreversible ischemic hand following intraarterial injection of zolpidem powder.

    • Ming-Yang Chang and Ja-Liang Lin.
    • Poison Center and Division of Nephrology, Chang Gung Memorial Hospital, Lin-Kou Medical Center, Medical College of Ghang Gung University, Taoyuan, Taiwan, ROC.
    • J. Toxicol. Clin. Toxicol. 2003 Jan 1;41(7):1025-8.

    AbstractIntraarterial injections of crushed oral formulations of drugs may cause acute, severe ischemia, and gangrene. A 24-yr-old woman developed severe ischemia of the right hand following arterial self-injection of a crushed zolpidem tablet. The first four digits of her right hand remained gangrenous even after treatment with heparinization, vasodilators, prostacyclin, and hyperbaric oxygen. Zolpidem tablets contain microcrystalline cellulose, an approved structural element in tablets for humans that has also been found to be a potent embolic agent. Microvascular embolization related to the microcrystalline cellulose may have contributed to the ischemia of the patient's hand.

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