• Huei-Chi Horng, Min-Tzung Ho, Chih-Hung Huang, Chun-Chang Yeh, and Chen-Hwan Cherng.
• Division of Anesthesiology, Taichung Armed Forces General Hospital, Taichung, Taiwan, Republic of China.
• Acta Anaesthesiol Taiwan. 2010 Sep 1;48(3):155-7.

AbstractNaloxone is commonly used to reverse narcotic intoxication. However, its use is not entirely free of hazards. For instance, pulmonary edema (PE) has been reported to arise with the mechanism of over-sympathetic discharge caused by release of cat-echolamine or central neurogenetic responses to narcotic reversal. Here, we report a healthy young patient who, after undergoing an uneventful uvulopalatopharyngo-plasty for obstructive sleep apnea hypopnea syndrome, developed PE following administration of naloxone. Fentanyl-induced respiratory depression was found during anesthesia emergence and thus naloxone was indicated for reversal. Unfortunately, upper airway obstruction-induced negative pressure PE occurred following naloxone administration. From this case, we suggest that a patent airway should be ascertained before naloxone administration for treating narcotic-induced respiratory depression.Copyright © 2010 Taiwan Society of Anesthesiologists. Published by Elsevier B.V. All rights reserved.

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