• Ann Pharmacother · Jan 2005

    Review

    High- versus low-dose oxytocin for augmentation or induction of labor.

    • John H Patka, Amy E Lodolce, and Angela K Johnston.
    • Department of Pharmacy and Drug Information, Grady Health System, Atlanta, GA 30303-3031, USA. jpatka@gmh.edu
    • Ann Pharmacother. 2005 Jan 1;39(1):95-101.

    ObjectiveTo compare the use of high- and low-dose oxytocin for augmentation or induction of labor.Data SourcesClinical trials were accessed through MEDLINE (1966-November 2003). Published literature relevant to the use of oxytocin for augmentation or induction of labor was evaluated.Study Selection And Data ExtractionArticles identified from the data sources were evaluated and included if they were clinical trials comparing high-versus low-dose oxytocin for augmentation or induction of labor.Data SynthesisOxytocin is a treatment of choice for augmentation and induction of labor; however, no consensus exists regarding optimal dosing. Relevant studies comparing high-dose (2-6 mU/min) and low-dose (1-2 mU/min) therapy for labor augmentation and induction were evaluated.ConclusionsHigh-dose oxytocin decreases the time from admission to vaginal delivery, but does not appear to decrease the incidence of cesarean sections when compared with low-dose therapy.

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