• Acta cirúrgica brasileira · Jan 2013

    Comparative Study

    The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats.

    • Vera Lucia Fernandes de Azevedo, Paulo Sergio Santana Santos, Gildàsio Silveira de Oliveira, Gabriel Pinheiro Módolo, Maria Aparecida Custódio Domingues, Yara Marcondes Machado Castiglia, Pedro Thadeu Galvão Vianna, Luiz Antonio Vane, and Norma Sueli Pinheiro Módolo.
    • Postgraduate Program in Anesthesiology, Botucatu Medical School, UNESP, Sao Paulo, Brazil.
    • Acta Cir Bras. 2013 Jan 1;28(1):5-9.

    PurposeTo compare fluid replacement therapy with Hydroxyethyl starch 6% (HES) versus Ringer's lactate (RL) in a rodent model of non-septic renal ischemia.MethodsForty male Wistar rats were randomized to receive HES 2 ml.kg(-1).hr(-1) or RL 5 ml.kg(-1).hr(-1) that underwent 30 minutes of renal ischemia followed by reperfusion. Twelve hours after kidney ischemia, the kidneys were evaluated for histological changes. Serum NGAL levels were obtained at different times of the experimental protocol.ResultsRodents in the HES group had a median (IQR) grade of renal injury 3 (3 to 5) compared to 2 (2 to 4) in the RL group (p=0.03). NGAL levels were not associated with the severity of kidney injury.ConclusionHydroxyethyl starch administration caused more kidney injury than Ringer's lactate in a non-infectious model of renal hypoperfusion.

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