• Oral Surg Oral Med Oral Pathol Oral Radiol · May 2013

    Review Meta Analysis Comparative Study

    The effect of tranexamic acid on blood loss in orthognathic surgery: a meta-analysis of randomized controlled trials.

    • Guodong Song, Ping Yang, Jing Hu, Songsong Zhu, Yunfeng Li, and Qiushi Wang.
    • Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu, China.
    • Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 May 1;115(5):595-600.

    ObjectiveThe objective of this article was to evaluate the efficacy of tranexamic acid on blood loss in orthognathic surgery. A meta-analysis was performed.Study DesignThe PubMed and EMBASE electronic databases were searched until June 30, 2012. Eligible studies were restricted to randomized controlled trials (RCTs).ResultsFour RCTs with 183 patients were included. The results showed that intraoperative blood loss in the tranexamic acid group was statistically reduced (weighted mean difference [WMD] = -93.56, 95% CI = -132.59-54.52, P < .00001). However, the postoperative levels of hemoglobin (Hb) and hematocrit (Hct) have no significant difference compared with placebo groups (WMD = 0.50, 95% CIs = -0.43-1.43, P = .29 and WMD = 0.18, 95% CIs = -1.64-1.99, P = .85, respectively).ConclusionsThis meta-analysis confirms that tranexamic acid can effectively reduce intraoperative blood loss in orthognathic surgery, especially by intravenous administration. But, tranexamic acid cannot affect postoperative levels of Hb and Hct.Copyright © 2013 Elsevier Inc. All rights reserved.

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