• Injury · Dec 2015

    Investigating a new drug delivery nano composite membrane system based on PVA/PCL and PVA/HA(PEG) for the controlled release of biopharmaceuticals for bone infections.

    • Taoyu Wan, George K Stylios, Marilena Giannoudi, and Peter V Giannoudis.
    • Nanjing University of Information and Engineering, Nanjing, Jiangsu, China; Research Institute for Flexible Materials (RIFleX), Heriot Watt University, Edinburgh, UK.
    • Injury. 2015 Dec 1; 46 Suppl 8: S39-43.

    AbstractThe capability for sustained and gradual release of pharmaceuticals is a major requirement in the development of a guided antimicrobial bacterial control system for clinical applications. In this study, PVA gels with varying constituents that were manufactured via a refreeze/thawing route, were found to have excellent potential for antimicrobial delivery for bone infections. Cefuroxime Sodium with poly(ethylene glycol) was incorporated into 2 delivery systems poly(e-caprolactone) (PCL) and hydroxyapatite (HA), by a modified emulsion process. Our results indicate that the Cefuroxime Sodium released from poly(e-caprolactone) in PVA was tailored to a sustained release over more than 45 days, while the release from hydroxyapatite PVA reach burst maximum after 20 days. These PVA hydrogel-systems were also capable of controlled and sustained release of other biopharmaceuticals.Copyright © 2015 Elsevier Ltd. All rights reserved.

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