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- Alessandra Stangherlin and Akhilesh B Reddy.
- From the Department of Clinical Neurosciences, University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, National Institute for Health Research (NIHR), Cambridge Biomedical Research Centre, Addenbrooke's Hospital, University of Cambridge, CB2 0QQ Cambridge, United Kingdom.
- J. Biol. Chem. 2013 Sep 13;288(37):26505-11.
AbstractLiving organisms possess biological clocks that resonate with environmental cycles in light, temperature, and food availability. Recently, circadian oscillations in the redox state of peroxiredoxin have been described as an additional non-transcriptional timekeeping mechanism. Of note, this redox cycle is conserved in both prokaryotes and eukaryotes. How the classical "transcription-translation feedback loop" model and this redox oscillation are related is still poorly understood. In this minireview, we describe the most recent evidence pointing to cross-talk between the circadian clock and the redox status of the cell.
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