• D Chassard, B Bryssine, F Golfier, C Raupp, D Raudrant, and P Boulétreau.
• Service d'anesthésie-reanimation, hôpital de l'Hôtel-Dieu, Lyon, France.
• Ann Fr Anesth Reanim. 1996 Jan 1;15(7):1013-7.

ObjectiveTo assess physiological changes and operating conditions during general anaesthesia with or without neuromuscular blockade in patients undergoing gynaecologic laparoscopy.Study DesignProspective, randomized, double-blind study.PatientsFifty non-obese patients, mean age 31 years, randomly allocated into either a group of 25 with curare (AC) or a group of 25 without curare (SC).MethodsAll patients were anaesthetized with propofol (2.5 mg.kg-1), sufentanil (0.4 microgram.kg-1) midazolam (2 mg) and N2O-O2. In addition, those of the AC group were given atracurium 0.25 mg.kg-1 for intubation, followed by additional boluses to maintain twitch height < 10% of the control value. Blood pressure, heart rate, peak airway pressure, end-tidal carbon dioxide pressure were recorded before and during pneumoperitoneum maintained at a pressure of 15 mmHg. Operating conditions were assessed at 10-min intervals, using a four point scale.ResultsIn both groups, blood pressure and heart rate decreased following induction. The decrease in blood pressure was more important in the SC group at 5 min and before pneumoperitoneum (25 vs 15%); P < 0.05). The time course of PETCO2 and peak airway pressures were similar between groups. Operating conditions were not influenced by the muscle relaxant.ConclusionsNeuromuscular blockade influences neither most of the clinical haemodynamic and respiratory changes induced by pneumoperitoneum for gynaecologic laparoscopy not the operating conditions.

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