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Randomized Controlled Trial Comparative Study Clinical Trial
A comparison of the pharmacodynamics of rocuronium and vecuronium during halothane anaesthesia.
- M G Booth, B Marsh, F M Bryden, E N Robertson, and W L Baird.
- Division of Anaesthesia, Royal Infirmary, Glasgow.
- Anaesthesia. 1992 Oct 1;47(10):832-4.
AbstractThirty healthy patients were randomised to receive either a single bolus dose of rocuronium 0.6 mg.kg-1 or vecuronium 0.1 mg.kg-1 during halothane anaesthesia. Onset time, duration 25, duration 75 and train-of-four 70 were measured. The onset of neuromuscular blockade following rocuronium was more rapid than vecuronium (p = 0.0001). All other pharmacodynamic parameters were similar. During the first minute following injection of the neuromuscular blocking agent, the heart rate increased by 36% in the rocuronium group but remained stable in those patients who received vecuronium (p = 0.0008). No adverse effects were noted in either group.
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