• Der Schmerz · Feb 2011

    Review

    [Pregabalin and postoperative hyperalgesia. A review].

    • A J Lederer, H Bornemann-Cimenti, M Wejbora, C Kern-Pirsch, K Michaeli, and A Sandner-Kiesling.
    • Universitätsklinik für Anästhesiologie und Intensivmedizin, Medizinische Universität Graz, Auenbruggerplatz 29, 8036 Graz, Austria.
    • Schmerz. 2011 Feb 1;25(1):12-8.

    AbstractNumerous studies support the theory that pregabalin causes an antihyperalgesic effect, which could be potentially beneficial in a perioperative setting. By binding to calcium channels pregabalin reduces the release of excitatory neurotransmitters and therefore inhibits central sensitization. Animal studies clearly demonstrated the antihyperalgesic potency of pregabalin but human experiments are, however, inconclusive. Clinical studies with quantitative sensory testing have not yet been published. Although strongly supported by theoretical considerations the routine preoperative application of pregabalin for the prevention of hyperalgesia cannot be recommended due to the lack of clinical studies. Future studies should incorporate secondary hyperalgesia and allodynia as primary parameters.

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