• Anesthesia and analgesia · Mar 2009

    Case Reports

    Treatment of serious calcium channel blocker overdose with levosimendan, a calcium sensitizer.

    • Tero Varpula, Janne Rapola, Marko Sallisalmi, and Jouni Kurola.
    • Department of Anesthesiology and Intensive Care Medicine, Jorvi Hospital, Turuntie 150, 02740 Espoo, Finland. tero.varpula@hus.fi
    • Anesth. Analg. 2009 Mar 1;108(3):790-2.

    AbstractCalcium channel blocker (CCB) overdose is often lethal. Conventional medical treatment includes i.v. calcium, high doses of catecholamines, insulin, and glucagon. A new inotropic drug, levosimendan, should be considered in severe CCB poisoning. Levosimendan's pharmacologic features differ from other inotropic drugs. It is a calcium sensitizer and improves contraction without increasing intracytosolic calcium concentration. We describe two patients with serious CCB overdose. Despite intensive medical and mechanical cardiovascular support, both patients remained in shock. Hemodynamics gradually improved after administration of levosimendan.

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