• The Journal of infection · Nov 2013

    Review Meta Analysis

    Commercial MPT64-based tests for rapid identification of Mycobacterium tuberculosis complex: a meta-analysis.

    • Xiaomao Yin, Lei Zheng, Li Lin, Yarong Hu, Fen Zheng, Yanwei Hu, and Qian Wang.
    • Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, No. 1838, North of Guangzhou Road, Baiyun District, Guangzhou 510515, PR China.
    • J. Infect. 2013 Nov 1;67(5):369-77.

    ObjectiveWe did a systematic review and meta-analysis of published studies to evaluate the accuracy of commercial MPT64-based immunochromatographic tests for rapid identification of Mycobacterium tuberculosis complex.MethodsWe identified studies by searching Pubmed, BIOSIS Previews and Web of Science, and included studies using predetermined inclusion criteria. The data were pooled using the DerSimonian-Laird random effects model.ResultsA total of 28 studies were included in the final analysis. Pooled estimates were 97% (confidence interval [CI] 96-97%) for sensitivity and 98% (CI 98-99%) for specificity. The summary receiver operating characteristic curve showed an area of 0.9968 and a Q* of 0.98. Subgroup analysis showed that test accuracy did not depend on commercial kit, reference test and medium.ConclusionsCommercial MPT64-based immunochromatographic tests are highly sensitive and specific for rapid identification of M. tuberculosis complex. They are good alternatives to biochemical test and molecular assays. Nevertheless, additional studies are required in setting with high prevalence of mpt64 mutations or high contamination of cultures.Copyright © 2013 The British Infection Association. Published by Elsevier Ltd. All rights reserved.

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