• Anesthesia and analgesia · Mar 2009

    Case Reports

    An exaggerated hypertensive response to glycopyrrolate therapy for bradycardia associated with high-dose dexmedetomidine.

    • Keira P Mason, Steven Zgleszewski, Roberta E Forman, Cynthia Stark, and James A DiNardo.
    • Department of Anesthesia, Perioperative and Pain Medicine, Children's Hospital Boston and Harvard Medical School, Boston, MA 02115, USA. keira.mason@childrens.harvard.edu
    • Anesth. Analg. 2009 Mar 1;108(3):906-8.

    AbstractAt our institution, high-dose i.v. dexmedetomidine is used to provide sedation for pediatric patients undergoing nonpainful radiological imaging studies. Some of these patients exhibit marked bradycardia (more than 20% deviation from the lowest age-adjusted normal values) while maintaining an arterial blood pressure within an acceptable normal range. We report on three cases wherein treatment of dexmedetomidine-induced bradycardia with i.v. glycopyrrolate (5.0 microg/kg) not only resulting in resolution of bradycardia but also resulting in an exaggerated increase of arterial blood pressure.

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