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Hematol. Oncol. Clin. North Am. · Feb 1990
ReviewThrombotic thrombocytopenic purpura and related disorders.
- P Ruggenenti and G Remuzzi.
- Ospedali Riuniti di Bergamo, Italy.
- Hematol. Oncol. Clin. North Am. 1990 Feb 1;4(1):219-41.
AbstractThis article provides us with background information on the disease. Clinical features, variants and classification, laboratory findings, and pathology are discussed. Knowledge of the disease's pathogenesis has increased recently and specific causes discussed are predisposing factors, triggering agents, endothelial damage, defective PGI2 bioavailability, FVIII/vWF multimeric structure abnormalities, platelet activation, and hemolytic anemia. Proposed specific therapies discussed are steroids, heparin, antiplatelet agents, prostacyclin, splenectomy, immunosuppressive agents, plasma infusion, and plasma exchange.
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