• Journal of neurosurgery · Jun 1981

    Case Reports

    Pharmacokinetics of epsilon-aminocaproic acid during peritoneal dialysis.

    • S S Fish, S Pancorbo, and R Berkseth.
    • J. Neurosurg. 1981 Jun 1;54(6):736-9.

    AbstractTwo patients requiring peritoneal dialysis were treated with epsilon-aminocaproic acid (EACA), an antifibrinolytic agent. Samples of serum and dialysate were assayed for EACA concentrations. Total body clearance, dialysis clearance, EACA half-life, and volume of distribution of EACA were calculated. Total body clearance of EACA was 26 ml/min, which is 25% of the drug clearance in patients with normal renal function. Our results suggest that patients undergoing peritoneal dialysis should receive 25% of the usual recommended dose of EACA. Dialysis clearance accounted for only 58% of total body clearance, suggesting an alternative route of elimination of EACA.

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