• Markus Weiss, Gabriele Schulz, Ian Teller, Alexander Dullenkopf, Anna Kolarova, Herrmann Sailer, Claudia M Dillier, Hans U Bucher, Andreas C Gerber, and Oskar Baenziger.
• Department of Anaesthesia, University Children's Hospital, Zurich, Switzerland. markus.weiss@kispi.unizh.ch
• Paediatr Anaesth. 2004 Dec 1;14(12):989-95.

BackgroundThe aim of the study was to compare liver tissue oxygenation determined by near infrared spectroscopy (NIRS) with central venous oxygen saturation (SvO(2)) and intestinal perfusion as measured by gastric intramucosal pH (pHi) in pediatric surgical patients.MethodsTwenty children undergoing craniofacial surgery with expected major intraoperative blood loss were studied. NIRS tissue oxygenation index (TOI(Liver)) and pHi values were recorded. Arterial blood gas analysis and SvO(2) were assessed from periodically taken blood samples. Data are presented as ranges (median) and were compared using linear regression analysis. Sensitivity and specificity of the intra-individual changes in TOI(Liver) to predict falling SvO(2) or pHi values were calculated.ResultsPatients age ranged from 0.79 to 8.27 years (1.92 years). TOI(Liver) ranged from 41.5 to 77.4% (61.5%), gastric pHi from 7.13 to 7.60 (7.37) and SvO(2) from 51 to 86% (74%). Among patients only moderate correlation was found between TOI(Liver) and SvO(2) (r = 0.594, P < 0.0001) and gastric pH(i) (r = 0.502, P < 0.0001). Intra-individual measured TOI(Liver) values, however, demonstrated close correlation with SvO(2) values (r = 0.680 to 0.976) but a varying correlation with gastric pHi values (r = 0.055 to 0.972). Sensitivity/specificity of TOI(Liver) to predict decreasing SvO(2) or gastric pHi values were 76.4/73.4% and 67.4/62.7% respectively.ConclusionsTOI(Liver) provided a better trend monitor of central venous oxygen saturation than gastric intramucosal pH. Because of its limited sensitivity and specificity to indicate deterioration of SvO(2), liver tissue oxygenation measured by transcutaneous NIRS does not provide additional practical information for clinical management.

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