• Comput. Biol. Med. · Jan 1994

    A model for analyzing the formation of thrombin in vessels.

    • T W Chung and E A O'Rear.
    • Department of Chemical Engineering, University of Oklahoma, Norman 73019.
    • Comput. Biol. Med. 1994 Jan 1;24(1):31-41.

    AbstractA pseudo steady-state model is proposed to analyze the effects of a vessel-length, blood-flow velocities, and the concentration levels of Va/Xa/phospholipid complex on the formation of thrombin in an arterial vessel. The outlet concentrations of thrombin are calculated in either physiological or pathological coagulation process. Among those factors, blood-flow velocity is the most important factor which affects the amount of thrombin formation. The model and its results might be used as a reference for those who clinically manage coagulation problems of patients with severe sepsis.

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