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J. Toxicol. Clin. Toxicol. · Jan 2000
Case ReportsHigh-efficiency dialysis for carbamazepine overdose.
- D J Schuerer, P D Brophy, N J Maxvold, T Kudelka, and T E Bunchman.
- C.S. Mott Children's Hospital, University of Michigan, Ann Arbor 48109, USA.
- J. Toxicol. Clin. Toxicol. 2000 Jan 1;38(3):321-3.
BackgroundCarbamazepine intoxication is associated with seizures, coma, arrhythmias, and death. In acute intoxications, charcoal hemoperfusion enhances removal of the drug but is associated with thrombocytopenia, coagulopathy, hypothermia, and hypocalcemia. Alternatively, high-efficiency hemodialysis can be used without the side effects of charcoal hemoperfusion.Case ReportWe report an 18-month-old comatose, convulsing child with plasma carbamazepine 27 microg/mL treated with high efficiency hemodialysis. Therapeutic carbamazepine levels were obtained after 4.5 hours of high-efficiency hemodialysis. The patient developed no untoward side effects, improved clinically, and was subsequently discharged home without sequelae. We conclude that high-efficiency hemodialysis is a safe, effective alternative to charcoal hemoperfusion in the pediatric population.
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