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J. Am. Acad. Dermatol. · Nov 1994
Case ReportsLinear IgA bullous dermatosis with autoantibodies to a 290 kd antigen of anchoring fibrils.
- G Zambruno, V Manca, J Kanitakis, E Cozzani, J F Nicolas, and A Giannetti.
- Department of Dermatology, University of Modena, Italy.
- J. Am. Acad. Dermatol. 1994 Nov 1;31(5 Pt 2):884-8.
AbstractWe describe a patient with a papulovesicular eruption associated with scarring and severe mucosal lesions that led to blindness. Direct immunofluorescence showed linear IgA deposits at the dermoepidermal junction. Indirect immunofluorescence microscopy showed that the patient's serum reacted with the dermal side of salt-split skin. Direct immunoelectron microscopy showed the IgA deposits to be associated with anchoring fibrils, whereas with Western blot analysis the patient's serum reacted with a 290 kd dermal antigen. On the basis of these findings, we suggest that our case may represent a form of IgA-mediated epidermolysis bullosa acquisita.
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