• R D Vincent, T J McNeil, C L Spaid, F R MacMahon, S J Maxwell, J S Brenner, and V L Schryer.
• Department of Anesthesia, U.S. Naval Hospital, Camp Lejeune, NC.
• J Clin Anesth. 1991 Jul 1; 3 (4): 285-9.

Study ObjectiveTo evaluate whether 360 ml of oral clear liquids consumed within 4 hours of elective surgery worsens gastric volume and acidity in patients given acid aspiration prophylaxis.DesignRandomized, unblinded study.SettingMain operating room at a U.S. military hospital.PatientsEighty-three adult inpatients scheduled to receive general anesthesia for elective surgery.InterventionsNineteen patients (Group 1) were given 150 mg of oral ranitidine (two doses), 10 mg of metoclopramide, and 360 ml of apple juice 3 hours before the scheduled start of surgery. Thirty-four patients (Group 2) fasted before surgery but received acid aspiration prophylaxis identical to that given to Group 1. Twenty-three additional patients (Group 3) received no oral fluids or acid aspiration prophylaxis before surgery.Measurements And Main ResultsThe residual gastric volume (RGV) and the pH of Group 1 patients were compared with measurements obtained in the two groups of patients who fasted. RGV measurements in Group 1 (14 +/- 3 ml) were similar to those in Group 2 (11 +/- 2 ml) and were significantly less than (p less than 0.05) those in Group 3 (26 +/- 4 ml). Gastric pH was significantly higher (p less than 0.001) in Group 1 (5.16 +/- 0.69) and Group 2 (5.78 +/- 0.43) than in Group 3 (1.97 +/- 0.27).ConclusionsThree hundred and sixty ml of apple juice consumed within 4 hours of elective surgery by patients given ranitidine and metoclopramide did not worsen gastric volume and acidity.

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