• Audrey Boulamery, Hafedh Marouani, Romain Guilhaumou, Emmanuelle Rocher, Nicolas Simon, and Bernard Bruguerolle.
• Laboratoire de Pharmacologie Médicale et Clinique (UPRES EA 3784:Variabilité pharmacologique), Faculté de Médecine de Marseille, Université de la Méditerranée, Marseille Cedex, France. audrey.boulamery@mail.ap-hm.fr
• Fundam Clin Pharmacol. 2008 Jun 1;22(3):285-9.

AbstractThe aim of this study was to document the influence of hyperthermia on the pharmacokinetics of ertapenem. Two groups of Wistar rats, normothermic (n = 6) and hyperthermic (n = 8), were injected a single intravenous bolus of ertapenem (15 mg/kg of body weight). Hyperthermia-induced animals were placed in a water-bath at 47 degrees C and control group animals were kept in a water-bath at 25 degrees C to obtain a stable mean core temperature of 39.8 and 36.9 degrees C respectively. Hyperthermia induced significant higher plasma concentrations and exposure, whereas total apparent clearance and volume of distribution were significantly decreased. If confirmed in humans, these results will be of interest to take into account such modifications in hyperthermic clinical situations.

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