• Der Schmerz · Nov 2007

    Multicenter Study

    [Oral transmucosal fentanyl citrate for the treatment of breakthrough pain. Results of a non-interventional study (NIS)].

    • R Zarth, M Ehmer, and H-B Sittig.
    • Abteilung für Anästhesie und Intensivmedizin, Zollernalb-Klinikum, Akademisches Lehrkrankenhaus der Universität Tübingen, Tübinger Str. 20/3 , 72336 Balingen, Deutschland. ralf.zarth@zollernalb-klinikum.de
    • Schmerz. 2007 Nov 1;21(6):545-52.

    BackgroundIn a non-interventional study the efficacy and tolerability of oral transmucosal fentanyl citrate (OTFC) was studied in patients with opioid-treated cancer pain suffering from breakthrough pain.Patients And MethodsThe prospective multicenter observational trial included 406 patients. For 3-4 months, efficacy of OTFC treatment for breakthrough pain was documented using a numerical analog pain intensity scale (NAS). Further, OTFC therapy was rated and adverse events were recorded.ResultsWith application of oral transmucosal fentanyl citrate median pain intensity fell from NAS 8 points at the beginning to NAS 2 points at the end of the study. The median effective dosage was 400 g. Tolerability was rated as good or very good by 87.5% of the patients.ConclusionOral transmucosal fentanyl citrate is a safe and effective treatment for breakthrough pain in chronic cancer-related pain.

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