• J W Devlin, G L Fraser, S Kanji, and R R Riker.
• Department of Pharmacy Services, Detroit Receiving Hospital, University Health Center, 4201 St. Antoine Blvd., Detroit, MI 48201-2403, USA. jdevlin@dmc.org
• Ann Pharmacother. 2001 Dec 1;35(12):1624-32.

ObjectiveTo review methods for assessing sedation in critically ill adults, discuss their impact on patient outcomes, and provide recommendations for implementing these methods into clinical practice in the intensive care unit (ICU).Data SourcesA computerized search of MEDLINE from 1980 through June 2000 and a manual search of abstracts presented at recent critical care meetings were performed.Study Selection And Data ExtractionSedation assessment tools that have been used to titrate therapy in adult, critically ill patients were identified. Special emphasis was placed on sedation assessment instruments that have been prospectively validated. Objective methods that have been used to assess sedation therapy were also identified.Data SynthesisTwenty-three adult sedation assessment instruments were identified. Few scales have been prospectively evaluated for validity (n = 6) or reliability (n = 7). Other methods of sedation assessment were identified (e.g., bispectral index monitor); however, most of these methods have only been studied in small subsets of critically ill patients.ConclusionsIncorporation of sedation assessment into ICU clinical practice may improve patient care. These sedation assessment instruments must be further evaluated to determine their impact on quality of care and ICU length of stay.

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