• Voprosy onkologii · Jan 2009

    Comparative Study Controlled Clinical Trial

    [Neoadjuvant therapy of breast cancer using Newcastle disease virus].

    • V V Keshelava, N Iu Dobrovol'skaia, N L Chazova, A M Bershchanskaia, M V Podol'skaia, T V Garmarnik, and N V Mel'nikova.
    • Vopr Onkol. 2009 Jan 1;55(4):433-5.

    AbstractThe role of Newcastle disease virus and neoadjuvant therapy was assessed in 84 cases of breast cancer T1-4N0-2M0 (2005-2008). Combined use of the virus vaccine and chemotherapy (group A), therapy with the vaccine alone (group B) and chemotherapy regimen identical with that used in group A (group C) were compared. Histological pattern of tumor and stage were identified using expression of receptors of steroid hormones, oncoproteins Her2/neu and p53 as well as proliferation activity (marker Ki-67) before and after therapy. It was shown that the efficiency and safety of Newcastle disease virus (apathogenic strain La-Sotha) met specific immuno- and neoadjuvant therapy standards.

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