• J Clin Anesth · Feb 2004

    Randomized Controlled Trial Clinical Trial

    Effects of droperidol dosage on postoperative emetic symptoms following pediatric strabismus surgery.

    • Stanley W Stead, Christopher D Beatie, Mary A Keyes, and Sherwin J Isenberg.
    • Department of Anesthesiology, Jules Stein Eye Institute, University of California at Los Angeles, Los Angeles, CA 90095, USA.
    • J Clin Anesth. 2004 Feb 1;16(1):34-9.

    Study ObjectiveTo compare the frequency of postoperative emetic symptoms and side effects in pediatric strabismus surgery using four doses of droperidol.DesignRandomized, blinded study.SettingUniversity eye institute.Patients82 ASA physical status I and II pediatric patients, aged 1 to 16 years, undergoing outpatient strabismus surgery.InterventionsPatients were assigned to one of four doses of droperidol (10, 20, 40, or 80 microg.kg(-1)) (Groups 1, 2, 3, and 4, respectively). All patients received the same anesthetic management, with droperidol administered intravenously immediately after induction of anesthesia.Measurements And Main ResultsPostoperatively, patients were evaluated for emetic symptoms (nausea, retching, and/or vomiting) and side effects (postoperative sedation or extrapyramidal symptoms). There was a dose-dependent reduction of emetic symptoms seen with increasing droperidol dose. Predischarge emetic symptoms were 50%, 15%, 15%, and 5% in Groups 1, 2, 3, and 4, respectively (p < 0.009). Peak emetic symptoms were observed after discharge: 75%, 40%, 35%, and 15% in Groups 1, 2, 3, and 4, respectively (p < 0.003). Convalescence times, including awakening, extubation, recovery, and hospitalization, were unaffected by increasing droperidol dose. Sedation was similar in all groups and no patient exhibited any side effects. However, when patients exhibited emetic symptoms, discharge time increased from 207 +/- 57 minutes to 283 +/- 128 minutes (p < 0.001).ConclusionsProphylactic administration of droperidol 80 microg.kg(-1) is most effective in reducing postoperative emetic symptoms without increasing time to discharge. In those patients with emetic symptoms who also received prophylactic droperidol, time to discharge was significantly delayed.

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