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J Burn Care Rehabil · Jan 2003
Comparative StudyComparison of silver sulfadiazine 1%, mupirocin 2%, and fusidic acid 2% for topical antibacterial effect in methicillin-resistant staphylococci-infected, full-skin thickness rat burn wounds.
- Cengiz Acikel, Oral Oncul, Ersin Ulkur, Ismail Bayram, Bahattin Celikoz, and Saban Cavuslu.
- Department of Plastic and Reconstructive Surgery and Burn Unit, Gülhane Military Medical Academy, Haydarpasa Training Hospital, Istanbul, Turkey.
- J Burn Care Rehabil. 2003 Jan 1;24(1):37-41.
AbstractSilver sulfadiazine 1%, mupirocin 2%, and fusidic acid 2% were compared to assess the antibacterial effect of a once-daily application on experimental rat 15% full-skin thickness burn wounds seeded 24 hours earlier with a 10 standard strain of methicillin-resistant staphylococci. The quantitative counts of seeded organism in burn eschar and subjacent muscle were determined at postburn day 7, beside the cultures of blood and lung biopsies. All tested topical agents were equally effective against methicillin-resistant in reducing local burn wound bacterial count and preventing systemic infection.
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