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Can J Clin Pharmacol · Jan 2004
Randomized Controlled Trial Comparative Study Clinical TrialEffects of age, gender and holding on pain response during infant immunization.
- Moshe Ipp, Anna Taddio, Morton Goldbach, Shlomit Ben David, Bonnie Stevens, and Gideon Koren.
- Department of Paediatrics, The Hospital for Sick Children, Toronto, Canada.
- Can J Clin Pharmacol. 2004 Jan 1;11(1):e2-7.
AbstractDeterminants of infant pain responses are important when assessing the efficacy of analgesics. In a randomized controlled trial, 106 infants aged 2 to 6 months were positioned either supine (SUP) on the examination table or held (HLD) by a parent during routine immunization in a community pediatric office. There was no difference between the SUP and HLD infants in duration of crying, facial grimacing or visual analogue scale (VAS) pain scores. Similarly gender did not affect pain response. In contrast, 2-month-old infants displayed more pain during immunization than did 4 or 6-month-old infants.
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