The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique
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Can J Clin Pharmacol · Jan 2004
Comparative Study Clinical TrialThe antidepressant effects of risperidone and olanzapine in bipolar disorder.
To describe the antidepressant effectiveness of olanzapine and risperidone and compare their tolerability when employed adjunctively in bipolar I/II disorder. ⋯ These pilot data, from the first prospective comparison study of risperidone and olanzapine in bipolar disorder, suggest that adjunctive administration of either agent may reduce depressive symptom severity. No subjects receiving risperidone or olanzapine developed tardive dyskinesia. Both compounds imparted substantial weight gain with significantly more weight gain accrual with olanzapine. As this was an observational study, the antidepressant effect and tolerability profile of these compounds requires validation via double-blind placebo controlled investigations.
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Can J Clin Pharmacol · Jan 2004
Randomized Controlled Trial Comparative Study Clinical TrialEffects of age, gender and holding on pain response during infant immunization.
Determinants of infant pain responses are important when assessing the efficacy of analgesics. In a randomized controlled trial, 106 infants aged 2 to 6 months were positioned either supine (SUP) on the examination table or held (HLD) by a parent during routine immunization in a community pediatric office. ⋯ Similarly gender did not affect pain response. In contrast, 2-month-old infants displayed more pain during immunization than did 4 or 6-month-old infants.
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Can J Clin Pharmacol · Jan 2004
Case ReportsAcute coronary syndrome induced by intravenous ephedrine in pregnant woman with normal coronaries.
Intravenous ephedrine administered during a C-section was observed to cause an acute coronary syndrome in a pregnant woman with normal coronaries. The patient developed sub-sternal chest pain, was noted to have 10 beats of non-sustained ventricular tachycardia, ST abnormalities were observed on her ECG and cardiac enzymes were elevated. The patient had normal coronary arteries by angiogram and during a one-year period of follow up no further cardiac events occurred.