• B F Keogh and V M Ranieri.
• Department of Anaesthesia and Intensive Care, Royal Brompton Hospital, London, UK.
• Br. Med. Bull. 1999 Jan 1;55(1):140-64.

AbstractVentilatory support in the acute respiratory distress syndrome (ARDS) has undergone considerable transformation in the 1990s. Current approaches include lung protective techniques which, while attempting to recruit and maintain lung volume, limit the shear stresses associated with ventilation by avoiding both alveolar overdistension and cyclical end-expiratory collapse. In addition, gas exchange targets have been liberalized and ventilatory conduct is much more tailored to individual pulmonary mechanics. Assessment of the inspiratory volume-pressure (V-P) curve provides information which can direct ventilator settings. Recent information from clinical trials has provided new insights into appropriate ventilatory modification and set the foundation for future clinical investigations.

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