• Biochim. Biophys. Acta · Jan 2012

    Review

    Relevance of mast cell-nerve interactions in intestinal nociception.

    • Sophie A van Diest, Oana I Stanisor, Guy E Boeckxstaens, Wouter J de Jonge, and René M van den Wijngaard.
    • Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands. s.a.vanDiest@AMC.UVA.NL
    • Biochim. Biophys. Acta. 2012 Jan 1;1822(1):74-84.

    AbstractCross-talk between the immune- and nervous-system is considered an important biological process in health and disease. Because mast cells are often strategically placed between nerves and surrounding (immune)-cells they may function as important intermediate cells. This review summarizes the current knowledge on bidirectional interaction between mast cells and nerves and its possible relevance in (inflammation-induced) increased nociception. Our main focus is on mast cell mediators involved in sensitization of TRP channels, thereby contributing to nociception, as well as neuron-released neuropeptides and their effects on mast cell activation. Furthermore we discuss mechanisms involved in physical mast cell-nerve interactions. This article is part of a Special Issue entitled: Mast cells in inflammation.Copyright © 2011 Elsevier B.V. All rights reserved.

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