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Ann Fr Anesth Reanim · Sep 2006
Case Reports[Use of activated recombinant FVII in the control of haemorrhage following trauma].
- V Perrier, N Morel, J-C Bernard, B Julliac, A Dewitte, O Pouquet, F Sztark, and P Dabadie.
- Département des urgences, CHU Pellegrin, place Amélie-Raba-Léon, 33076 Bordeaux cedex, France.
- Ann Fr Anesth Reanim. 2006 Sep 1;25(9):990-3.
AbstractUncontrolled haemorrhage is a major cause of death in trauma patients: sometimes inaccessible to surgery and often associated with coagulopathy. We report a case of severe blunt pelvic trauma associated with suicide. The conventional treatments were unsuccessful and embolization was impossible. The patient required massive blood product transfusion. A 100 microg/kg recombinant activated factor VII dose was infused, twice. After administration of the first dose, the blood requirement decreased dramatically. Further work and trials are required to assess the safety profile and dose regimen for this drug.
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