• L Pantoni, A M Basile, M Romanelli, C Piccini, C Sarti, P Nencini, and D Inzitari.
• Department of Neurological and Psychiatric Sciences, University of Florence, Viale Morgagni 85, 50134 Florence, Italy. pantoni@neuro.unifi.it
• Acta Neurol. Scand. 2001 Sep 1;104(3):185-90.

BackgroundAn internal capsule genu infarct has been rarely reported to cause cognitive impairment and behavioral changes. This clinical picture can be explained on anatomical and functional basis because important subcortical-cortical pathways traverse the internal capsule genu. We report 2 previously non-demented patients who developed acute confusional state, abulia, and moderate cognitive decline after the occurrence of an infarct in the capsular genu.MethodsClinical, neuropsychological, and MRI evaluation at baseline and 12-month follow-up.ResultsAbulia and cognitive impairment were still present 1 year after stroke. In 1 patient there were associated multiple lacunar infarcts and leukoaraiosis. In the other an old small left frontal infarct was also present. In both moderate cortical atrophy co-existed.ConclusionsWe hypothesize that co-existing lesions, possibly associated with a sub-clinical reduction of cognitive functions, facilitate the development of a persistent clinically evident mental deficit after the occurrence of an infarct in the capsular genu.

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