• Biomarkers · Feb 2014

    Comparative Study Observational Study

    Neutrophil gelatinase-associated lipocalin after off pump versus on pump coronary artery surgery.

    • Miklos Lipcsey, Philip Hayward, Michael Haase, Ania Haase-Fielitz, Glenn Eastwood, Leah Peck, George Matalanis, and Rinaldo Bellomo.
    • Department of Surgical sciences, Section of Anaesthesiology & Intensive Care, Uppsala University , Uppsala , Sweden .
    • Biomarkers. 2014 Feb 1;19(1):22-8.

    ContextCardiac surgery.ObjectiveTo compare plasma and urinary neutrophil gelatinase-associated lipocalin (P-/U-NGAL) in on-pump (n = 43) versus off-pump (n = 40) surgery.Materials And MethodsWe obtained perioperative P-/U-NGAL and outcome data.ResultsP-/U-NGAL increased after surgery. P-NGAL was higher post-surgery in on pump patients (139 versus 67 µg L(-1); p < 0.001), but not at 24 h. There were no differences in U-NGAL. Correlation between P-/U-NGAL and plasma creatinine was weak.DiscussionP-NGAL acts like a neutrophil activation biomarker and U-NGAL like a tubular injury marker.ConclusionOn-pump patients had greater neutrophil activation. On- versus off-pump surgery had similar impact on tubular cells.

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