Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
-
Comparative Study Observational Study
Neutrophil gelatinase-associated lipocalin after off pump versus on pump coronary artery surgery.
Cardiac surgery. ⋯ On-pump patients had greater neutrophil activation. On- versus off-pump surgery had similar impact on tubular cells.
-
Establish the prognostic value for graft loss of urinary neutrophil gelatinase-associated lipocalin (uNGAL), kidney injury molecule-1 (uKIM-1), interleukin-18 (uIL-18), and heat shock protein 72 (uHsp72) in kidney transplant recipients (KTR) with acute kidney injury (AKI). ⋯ After 1 year, 11 KTR with graft loss had higher uNGAL compared to KTR without loss (p < 0.001). There were no differences for uKIM-1, uIL-18 and uHsp-72. uNGAL >200 ng/mL had 84% sensitivity and 86% specificity for graft loss (ROC AUC: 0.89, 95% CI: 0.81-0.97). uNGAL may be useful to predict graft loss after AKI.