• Teresa Chavarría-Pérez, Carlos Fernando Cabrera-Leal, Susana Ramírez-Vargas, José Luis Reynada, and César Alejandro Arce-Salinas.
• Servicio de Anestesiología, Hospital Central Sur de Alta Especialidad de Petróleos Mexicanos, Distrito Federal, México. drcabrera7@icloud.com.
• Rev Med Inst Mex Seguro Soc. 2015 May 1; 53 (3): 274-8.

BackgroundIt is unknown which analgesic modality gives better results after a laparoscopic cholecystectomy. The aim of this study was to compare the analgesic efficacy of ropivacaine for local use against that of intravenous dipyrone in laparoscopic cholecystectomy.MethodsA non-inferiority randomized clinical trial. Fifty patients with laparoscopic cholecystectomy were included into two separate groups.Intervention0.75 % ropivacaine infiltrated at the trocar insertion sites and in the gallbladder fossa compared with intravenous dipyrone.MeasurementsThe primary outcome was pain, which was assessed using the visual analog scale during the first 24 hours. Secondary outcomes were the presence of adverse effects, and the need for analgesic rescue with tramadol.ResultsThe visual analog scale average for pain at the conclusion of the surgery was 3.8 in the ropivacaine vs. 3.56 in the dipyrone groups, while at 6, 12 and 24 hours the values were 2.64, 1.92 and 1.28, respectively, for ropivacaine versus 2.6, 1.88 and 1.2, respectively, for dipyrone. No adverse effects were observed in either group, and the two groups exhibited similar needs for analgesic rescue with tramadol.ConclusionsInfiltration of 0.75 % ropivacaine at the trocar insertion sites and the gallbladder exhibits analgesia similar to IV dipyrone during the first 24 hours post-laparoscopic cholecystectomy without adverse effects.

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