• Xin Tu.
• Intensive Care Unit, Shaoxing People's Hospital, Zhejiang 312000, China.
• Zhonghua Jie He He Hu Xi Za Zhi. 2004 Dec 1;27(12):829-32.

ObjectiveTo evaluate the effects of rapid shallow breathing index (RSBI), airway occlusion pressure (P(0.1)) and traditional weaning predictors in the weaning process for patients undergoing prolonged mechanical ventilation.MethodsHaving past 60-min spontaneous breathing trial and satisfied at least 8 of 10 traditional weaning predictors, 80 patients fulfilled the criteria of discontinuing ventilation and were included in the study. The coordinate capability of breath movement, the quantity of sputum, the quantity of rales in the lungs, the efficiency of coughing, respiratory rate, tidal volume, minute ventilation, compliance of the respiratory system, pulse oxygen saturation, pH value of the arterial blood, RSBI and P(0.1) were determined. According to the outcome of weaning from mechanical ventilation, patients were divided into a failure group and a success group. T test, chi-square test and Logistic regression analysis were used for statistics analysis.ResultsSixteen (20%) patients failed weaning. By univariate analysis, the average age, RSBI and P(0.1) values were significantly different between the failure and the success groups (P < 0.05). Logistic regression analysis with weaning outcome as the dependent variable, RSBI [(71 +/- 23) breaths.min(-1).L(-1), (53 +/- 13) breaths.min(-1).L(-1), OR = 1.03] and P(0.1) [(7.4 +/- 2.1) cm H2O, (3.6 +/- 1.4) cm H2O, OR = 6.87] were the only significant variables in the model. Using RSBI breaths.min(-1).L(-1) as the threshold value for predicting successful weaning, the sensitivity, specificity and accuracy were 90%, 36% and 78% respectively. Using P(0.1) ConclusionsIn the weaning process for patients undergoing prolonged mechanical ventilation, RSBI and P(0.1) are valuable and accurate predictors. Traditional weaning predictors may be useless.

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