• Eric C Donny, Dorothy K Hatsukami, Neal L Benowitz, Alan F Sved, Jennifer W Tidey, and Rachel N Cassidy.
• Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA. Electronic address: edonny@pitt.edu.
• Prev Med. 2014 Nov 1; 68: 172217-22.

IntroductionBoth the Tobacco Control Act in the U.S. and Article 9 of the Framework Convention on Tobacco Control enable governments to directly address the addictiveness of combustible tobacco by reducing nicotine through product standards. Although nicotine may have some harmful effects, the detrimental health effects of smoked tobacco are primarily due to non-nicotine constituents. Hence, the health effects of nicotine reduction would likely be determined by changes in behavior that result in changes in smoke exposure.MethodsHerein, we review the current evidence on nicotine reduction and discuss some of the challenges in establishing the empirical basis for regulatory decisions.ResultsTo date, research suggests that very low nicotine content cigarettes produce a desirable set of outcomes, including reduced exposure to nicotine, reduced smoking, and reduced dependence, without significant safety concerns. However, much is still unknown, including the effects of gradual versus abrupt changes in nicotine content, effects in vulnerable populations, and impact on youth.DiscussionA coordinated effort must be made to provide the best possible scientific basis for regulatory decisions. The outcome of this effort may provide the foundation for a novel approach to tobacco control that dramatically reduces the devastating health consequences of smoked tobacco.Copyright © 2014 Elsevier Inc. All rights reserved.

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