• B Kress, D Rasche, J Fiebach, V Tronnier, K Sartor, and C Stippich.
• Abteilung Neuroradiologie, Neurologische Klinik, Universitätsklinikum Heidelberg. Bodo_Kress@med.uni-heidelberg.de
• Rofo. 2004 May 1;176(5):719-23.

PurposeTo assess whether MRI can detect atrophy of the trigeminal nerve in patients with trigeminal neuralgia.Materials And MethodsA prospective MRI study was conducted in 39 patients (trigeminal neuralgia, trigeminal neuropathy, or atypical facial pain) and 25 volunteers. Using a coronal orientation (T1 Flash 3D; T2 CISS 3D), regions of interest were delineated in the cisternal part of the trigeminal nerve along the border of the nerve to calculate the volume of the nerve. The volume of the nerve was compared side-by-side in each patient (t-test, p < 0.05) and the volume difference compared between patients and volunteers.ResultsThe volume of the compromised trigeminal nerve in patients with trigeminal neuralgia was lower than on the contralateral healthy side, with the difference between healthy and compromised side statistically significant (p < 0.05). In all other patients and in all volunteers, no significant difference was found between the volume of the healthy and compromised nerve. The volume difference between the healthy and compromised side in patients with trigeminal neuralgia was significantly higher (p < 0.05) than in all other patients and volunteers.ConclusionAtrophy of the trigeminal nerve caused by a nerve-vessel conflict can be detected by MRI. Only patients with trigeminal neuralgia show this unilateral atrophy. Therefore, it is possible to demonstrate the result of the nerve-vessel conflict and to determine the consequences of such a conflict.

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