• Anaesthesia · Aug 1986

    Randomized Controlled Trial Comparative Study Clinical Trial

    Oral lormetazepam in premedication. A comparison with diazepam.

    • C J Jakobsen, J J Jensen, W Hansen, and N Grabe.
    • Anaesthesia. 1986 Aug 1;41(8):870-3.

    AbstractLormetazepam, a relatively new benzodiazepine was compared in a randomised, double blind trial with diazepam for its effectiveness as an oral premedicant drug. A scoring system was used to assess sedation, relief of anxiety, nausea, dizziness and cardiovascular effects in two groups of patients having orthopaedic operations. Some statistical indication that lormetazepam has a greater anxiolytic effect than diazepam was found, but in assessing total effect using a known scoring system, no difference was demonstrated between the two drugs.

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